Chromosomes in Human Cancer
نویسندگان
چکیده
منابع مشابه
Chromosomes of human cancer cells.
Obvious mitotic abnormalities have long been known to occur very commonly in malignant tumours, but as a result of recent improvements in technique much more reliable cytogenetic observations are now possible. Transplantable tumours were the first to be accurately examined, and these were found to consist of populations of cells with variations around a modal (" stemline ") type which differs i...
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Three male patients with leukemia were found with banding techniques to have unusual cytogenetic pictures in the cells of their marrow, spleen or blood. Case No. 1 (78 yr old) was that of a Ph’-negative CML with a missing Y in the blood (cultured without PHA) and marrow cells. The patient is still alive and responding to therapy. Case No. 2 (54 yr old) was considered prior to admission to have ...
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Double minute chromosomes are cytogenetic manifestations of gene amplification frequently seen in cancer cells. Genes amplified on double minute chromosomes include oncogenes and multi-drug resistant genes. These genes encode proteins which contribute to cancer formation, cancer progression, and development of resistance to drugs used in cancer treatment. Elimination of double minute chromosome...
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Though reported from a wide variety of human neoplasias, ring chromosomes, in general, are a rare finding in these diseases. The majority were detected by chance when tumors were screened for chromosomal aberrations. In most cases they are a part of highly complex karyotypic alterations and therefore part of unfavourable prognostic factors. However, in some tumor entities (e.g. tumors of mesenc...
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About 70 scientists recently attended the conference on " Aneuploidy and Cancer " in Oakland, CA, which was organized by P. Duesberg and D. Rasnick from the University of California, Berkeley, and generously sponsored by philanthropist Robert Leppo. The conference explored whether aneuploidy, i.e., specific ge-nomic imbalances, is a driving force behind the development of cancer. A century ago ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1974
ISSN: 0021-9746
DOI: 10.1136/jcp.27.4.340-a