Chromosome Polymorphism and Human Pathology: About 27 Cases of Chromosome 9 Inversion in the Beninese Population
نویسندگان
چکیده
The chromosomal polymorphism defined by variations of some regions a person (the constitutive heterochromatin and the short arms acrocentric chromosomes (13 to 15 21 - 22)) sometimes highlighted problems with regard their safety pathogenicity. Polymorphisms are usually found in same family transmitted dominant Mendelian. Chromosome 9 inversion is frequent phenomenon that cytogeneticists consider as variant normal. Despite its classification minor chromosome rearrangement which does not correspond abnormal phenotypes, many reports have raised conflicting opinions well, complete controversial. 27 cases were identified our laboratory. main indications for karyotype case inv (9) congenital cardiopathy (18.5%), sex development disorders down syndrome infertility (14.8%). This study stood out observations authors who involvement genesis several pathologies.
منابع مشابه
Goldenhar Syndrome and Pericentric Inversion of Chromosome 9
Oculo-auriculovertebral dysplasia (Goldenhar) is a congenital syndrome. Its phenotype differs from craniofacial anomalies to cardiac, vertebral or central nervous system defects. This syndrome is rare and its etiology is not apparent yet. Pericentric inversion of chromosome 9 is one of the most common structural balanced chromosomal aberrations with its incidences 15% to 25%. Herein we present ...
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ژورنال
عنوان ژورنال: Open Journal of Genetics
سال: 2021
ISSN: ['2162-4461', '2162-4453']
DOI: https://doi.org/10.4236/ojgen.2021.113003