منابع مشابه
Effect of gonadotropins on chromosome aneuploidy, chromosome mosaicism & sex ratio in mouse preimplantation embryos.
BACKGROUND & OBJECTIVE There are potential risks of major birth defect in IVF (in vitro fertilization) pregnancy as well as IVF-ICSI (intra cytoplasmic sperm injection) pregnancies in comparison with naturally conceived human pregnancies. This increase risk could be due to either gonadotropins used for ovarian stimulation or in vitro culture conditions or multiple pregnancy or combinations of a...
متن کاملChromosome abnormalities in human embryos.
The presence of numerical chromosome abnormalities in human embryos was studied using fluorescence in-situ hybridization with four or more chromosome-specific probes. When most cells of an embryo are analysed, this technique allows differentiation to be made between aneuploidy, mosaicism, haploidy and polyploidy. Abnormal types of fertilization, such as unipronucleated, tripronucleated zygotes ...
متن کاملChromosomal mosaicism in human preimplantation embryos: a systematic review.
BACKGROUND Although chromosomal mosaicism in human preimplantation embryos has been described for almost two decades, its exact prevalence is still unknown. The prevalence of mosaicism is important in the context of preimplantation genetic screening in which the chromosomal status of an embryo is determined by the analysis of a single cell from that embryo. METHODS Here we report a systematic...
متن کاملAnaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryos.
BACKGROUND Cleavage stage embryos as well as postimplantation embryos have been studied extensively over the years. However, our knowledge with respect to the chromosomal constitution of human embryos at the blastocyst stage is still rudimentary. METHODS In the present paper, a large series of human blastocysts was examined by means of fluorescent in situ hybridization (FISH). RESULTS It wa...
متن کاملTreatment-related chromosome abnormalities in human embryos.
Mosaicism was studied in good quality embryos from four different centres in order to assess the effects of follicular induction and exposure to laboratory conditions on chromosomal status. The donated embryos were fully biopsied and analysed by fluorescence in-situ hybridization using probes for chromosomes X, Y, 13, 18 and 21, simultaneously. The number of abnormal cells present indicated the...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1994
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod51.3.373