Chromosome Axis Defects Induce a Checkpoint-Mediated Delay and Interchromosomal Effect on Crossing Over during Drosophila Meiosis
نویسندگان
چکیده
منابع مشابه
Chromosome Axis Defects Induce a Checkpoint-Mediated Delay and Interchromosomal Effect on Crossing Over during Drosophila Meiosis
Crossovers mediate the accurate segregation of homologous chromosomes during meiosis. The widely conserved pch2 gene of Drosophila melanogaster is required for a pachytene checkpoint that delays prophase progression when genes necessary for DSB repair and crossover formation are defective. However, the underlying process that the pachytene checkpoint is monitoring remains unclear. Here we have ...
متن کاملInterchromosomal Effects on Crossing over in Drosophila Melanogaster. Ii.a Reexamination of X Chromosome Inversion Effects.
NTEREST in interchromosomal effects on crossing over in Drosophila melanoIgaster has been renewed recently (COOPER, ZIMMERING and KRIVSHENKO 1955; OKSALA 1958; HART and SANDLER 1961; RAMEL 1962; SUZUKI 1962a; ROBERTS 1962). As a result of the new approaches taken in these studies, two general types of mechanisms, one physiological in nature ( STEINBERG and FRASER 1944; RAMEL 1962; ROBERTS 1962)...
متن کاملInterchromosomal effects on crossing-over in Drosophila melanogaster. I. Effects of compound and ring X chromosomes on the third chromosome.
LTHOUGH the properties of crossing-over have been investigated extenA sively in Drosophila melanogaster, the influence of nonhomologous chromosomes on crossing-over is a problem that warrants further exploration. Since STURTEVANT’S (1919) observation that a heterozygous inversion in the third chromosome increased crossing-over in chromosome 2, many investigators such as SCHULTZ and REDFIELD in ...
متن کاملInter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3
In this study we have analysed AtASY3, a coiled-coil domain protein that is required for normal meiosis in Arabidopsis. Analysis of an Atasy3-1 mutant reveals that loss of the protein compromises chromosome axis formation and results in reduced numbers of meiotic crossovers (COs). Although the frequency of DNA double-strand breaks (DSBs) appears moderately reduced in Atasy3-1, the main recombin...
متن کاملThe Effect of Autosomal Inversions on Crossing over in the X-Chromosome of Drosophila Melanogaster.
HE first evidence of a crossover suppressor was found in 1913 by T STURTEVANT. In 1921 STURTEVANT found the first definite evidence of an inversion when he showed that several third chromosome genes in Drosophila melanogaster were arranged in an inverted order with respect to similar genes in the third chromosome of D. simulans. At this time STURTEVANT predicted that a heterozygous inversion wo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2010
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1001059