Chromosome 6q24-related diabetes mellitus

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MALNUTRITION-RELATED DIABETES MELLITUS IN SOUTHERN IRAN

Malnutrition-related diabetes mellitus (MRDM) is a major form of secondary diabetes, restricted to tropical developing countries. We studied 200 cases of diabetes mellitus aged 6-18 years in Fars Province to find the prevalence of MRDM. There were 14 cases who had clinical and laboratory findings compatible with MRDM. The mean age at presentation was 8.6±3 years, with a male to female ratio...

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malnutrition-related diabetes mellitus in southern iran

malnutrition-related diabetes mellitus (mrdm) is a major form of secondary diabetes, restricted to tropical developing countries. we studied 200 cases of diabetes mellitus aged 6-18 years in fars province to find the prevalence of mrdm. there were 14 cases who had clinical and laboratory findings compatible with mrdm. the mean age at presentation was 8.6±3 years, with a male to female ratio of3...

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Chromosome 6q24 methylation defects are uncommon in childhood-onset non-autoimmune diabetes mellitus patients born appropriate- or large-for-gestational age

Methylation defects in the imprinting locus at chromosome 6q24 result in transient neonatal diabetes and small-for-gestational age (SGA) births (1). These phenotypes are primarily ascribed to the overexpression of PLAGL1, a paternally expressed gene on 6q24 that regulates cell cycle and apoptosis (2). Paternal uniparental disomy involving 6q24, as well as copy-number gains of paternal PLAGL1 al...

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Malnutrition-related Diabetes Mellitus in Africa

Diabetes mellitus was thought to be rare in Africans up to the 1930’s and even up to the sixties in some countries [1]. However, subsequent hospital-based observations have confirmed that it is not uncommon. Both Type 1 and Type 2 diabetes are seen, the latter being much more common. More recently, an apparent increase in the incidence of Type 2 has been observed in association with the adoptio...

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ژورنال

عنوان ژورنال: Clinical Pediatric Endocrinology

سال: 2018

ISSN: 0918-5739,1347-7358

DOI: 10.1297/cpe.27.59