Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification.
Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population in the peripheral blood with fewer than 5 × 10(9)/L B-cells and no other signs of a lymphoproliferative disorder. The majority of cases of MBL have the immunophenotype of chronic lymphocytic leukemia (CLL). MBL can be categorized as either low count or high count based on whether the B-cell count is above ...
متن کاملLow frequency mutations independently predict poor treatment-free survival in early stage chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
Recent studies employing next generation sequencing (NGS) technologies have identified novel recurring mutations in monoclonal B-cell lymphocytosis (cMBL) and chronic lymphocytic leukemia (CLL).NOTCH1 and SF3B1 mutations are the most prevalent and are associated with reduced survival independent of established clinical and biological variables. However, we have limited understanding of the impa...
متن کاملReview Series CHRONIC LYMPHOCYTIC LEUKEMIA: TAKING A BIG LEAP FORWARD Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder characterized by .5 3 10/L peripheral B-lymphocytes coexpressing CD5, CD19, and CD23 and a weak expression of CD20, CD79b, and surface immunoglobulin (sIg). When such a population is detected in enlarged lymph nodes of patients without peripheral lymphocytes, the term small lymphocytic lymphoma (SLL) is used, indicating...
متن کاملTelomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic clinical entity characterized by the proliferation of monoclonal B cells not meeting the diagnosis criteria for chronic lymphocytic leukemia (CLL). MBL may precede the development of CLL, but the molecular mechanisms responsible for disease progression and evolution are not completely known. Telomeres are usually short in CLL and their at...
متن کاملFrequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
INTRODUCTION Monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x10(9)/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2012
ISSN: 0361-8609
DOI: 10.1002/ajh.23340