Chromosomal translocation t(X;11)(q22;q23) involving the MLL gene

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The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia.

Reciprocal chromosomal translocations are recurrent features of many hematological malignancies. The cloning of the genes located at the breakpoints of chromosomal translocations in leukemia and lymphoma has led to the identification of new genes involved in carcinogenesis. Molecular studies of the breakpoint of several translocations involving chromosomal band 11q23 led to the cloning of a gen...

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Panhandle polymerase chain reaction amplifies MLL genomic translocation breakpoint involving unknown partner gene.

We used a new approach called panhandle polymerase chain reaction (PCR) to clone an MLL genomic translocation breakpoint in a case of acute lymphoblastic leukemia of infancy in which karyotype analysis was technically unsuccessful and did not show the translocation partner. Panhandle PCR amplified known MLL sequence 5' of the breakpoint and 3' sequence from the unknown partner gene from a DNA t...

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Chromosomal translocations are implicated as important pathogenetic events in many human malignancies (1) . For tumors of B-lymphoid origin, the Ig genes are frequent sites of chromosomal translocations, most commonly resulting in juxtaposition of Ig genes with the c-myc or bcl-2 genes (2) . In rare T cell cancers, the TCR-a gene may be translocated into close proximity of the c-myc protooncoge...

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ژورنال

عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology

سال: 2012

ISSN: 1768-3262

DOI: 10.4267/2042/46953