Chromosomal abnormality, megaloblastosis, and arrested DNA synthesis in erythroleukaemia.

Chromosomal abnormality, megaloblastosis, and arrested DNA synthesis in erythroleukaemia.

Chromosomal studies of bone-marrow cells have been reported on 30 patients with erythroleukaemia (Table I). Some of these reports give only meagre cytogenetic details, but there was an increased degree of polyploidy in at least 9 of the patients, significant aneuploidy in 12, and structural abnormalities in 11. Some patients showed more than one of these features, and only 8 patients had normal...

Chromosomal Abnormality in Men with Impaired Spermatogenesis

Biochemical Abnormality of DNA Synthesis

Six patients with acute and chronic myeloid leukemia (AML and CML) showed a low incorporation of labeled DNA precursors into basophilic erythroblasts. Based on mitotic indices and the use of vincristine as a stathmokinetic tool, it was evident that brisk proliferation in this cell compartment took place. Mic rospectrophotometric determination of single-cell DNA content showed that a considerabl...

Consanguinity and chromosomal abnormality

BACKGROUND: Consanguinity is defined as the marriage between close relatives. The deleterious effects associated with consanguinity may be caused by the expression of rare recessive genes inherited from common ancestors. AIMS AND OBJECTIVES: The present study was undertaken to analyze the effect of consanguinity on chromosomal abnormality (CA). METHODS AND MATERIALS: During last 6 years period,...

Dna Synthesis and Chromosomal Asynchrony

A number of studies investigating the chronology of D N A synthesis in human chromosomes have indicated a degree of asynchrony among the members of the complement. The most striking asynchrony of D N A synthesis demonstrated within pairs of human chromosomes is the late replication of one of the X chromosomes shown by pulse labeling with tritiated thymidine in cultures of leucocytes (3, 4, 7, 8...