Chromatin remodeling and cancer, part II: ATP-dependent chromatin remodeling
نویسندگان
چکیده
منابع مشابه
ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling
Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven chromatin assembly and chromatin remodeling in the generation of periodic nucleosome arrays. We found that chromatin remodeling-defective Chd1 motor ...
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The eukaryotic genome is packaged into a periodic nucleoprotein structure termed chromatin. The repeating unit of chromatin, the nucleosome, consists of DNA that is wound nearly two times around an octamer of histone proteins. To facilitate DNA-directed processes in chromatin, it is often necessary to rearrange or to mobilize the nucleosomes. This remodeling of the nucleosomes is achieved by th...
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Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin and, hence, regulate gene expression. These complexes contain diverse subunits that together provide a multitude of functions, from early emb...
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It has become widely accepted that modification of nucleosome structure is an important regulatory mechanism. The hypothesis that the acetylation of histones is involved in regulation was first formed over thirty years ago by Allfrey and colleagues (Allfrey et al. 1964). Subsequent genetic studies suggested that complexes that utilize ATP hydrolysis to alter chromatin structure might also play ...
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The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic stability. Two pathways for the repair of DBSs, nonhomologous end-joining (NHEJ) and homologous recombination (HR), have evolved in eukaryotes. These pathways, like processes such as transcription and replication, act on DNA that is embedded in nucleosomes. Recent studies have shown that DNA repair, like tr...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2007
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2007.07.004