منابع مشابه
Roles of Chromatin insulators in gene regulation and diseases
With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of c...
متن کاملChromatin loops, gene positioning, and gene expression
Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen receptor loci, the imprinted H19-Igf2 locus and the Hox gene clusters. Collectivel...
متن کاملroles of chromatin insulators in gene regulation and diseases
with advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. chromatin insulators are key determinants of proper gene regulation and precise organization of c...
متن کاملChromatin, Gene, and RNA Regulation
Members of the Ewing sarcoma family of tumors (ESFT) contain tumor-associated translocations that give rise to oncogenic transcription factors, most commonly EWS/FLI1. EWS/FLI1 plays a dominant role in tumor progression by modulating the expression of hundreds of target genes. Here, the impact of EWS/FLI1 inhibition, by RNAi-mediated knockdown, on cellular signaling was investigated using mass ...
متن کاملChromatin Switches and Loops
A mechanism reveals how Swi6 spreads heterochromatin, silencing gene expression. HP1 Spreads the Word A classic example of how chromatin architecture regulates gene expression is the formation and spread of heterochromatin, a repressive state marked by histone H3 lysine 9 methylation (H3K9Me). In humans, heterochromatin protein 1 (HP1) binds to H3K9Me and is required for spreading of heterochro...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2009
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2008.07.002