Chondroitinase ABC promotes selective reactivation of somatosensory cortex in squirrel monkeys after a cervical dorsal column lesion

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Chondroitinase ABC promotes selective reactivation of somatosensory cortex in squirrel monkeys after a cervical dorsal column lesion.

After large but incomplete lesions of ascending dorsal column afferents in the cervical spinal cord, the hand representation in the contralateral primary somatosensory cortex (area 3b) of monkeys is largely or completely unresponsive to touch on the hand. However, after weeks of spontaneous recovery, considerable reactivation of the hand territory in area 3b can occur. Because the reactivation ...

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Reorganization of Somatosensory Cortex Subsequent to Dorsal Column Injury: a Study of the Marmoset and the Squirrel Monkey

For my grandmother, a quiet, dignified woman. iii ACKNOWLEDGEMENTS This work would not have been possible without the financial support of the Christopher and Dana Reeve foundation, and for this I thank them. I would like to thank my advisor Jon Kaas for his support and for his many words of wisdom. He is truly an inspirational man. I thank my committee members Troy Hackett, Sohee Park, and For...

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Reorganization of somatosensory cortical areas 3b and 1 after unilateral section of dorsal columns of the spinal cord in squirrel monkeys.

An incomplete lesion of the ascending afferents from the hand in the dorsal columns of the spinal cord in monkeys is followed after weeks of recovery by a reactivation of much of the territory of the hand representations in primary somatosensory cortex (area 3b). However, the relationship between the extent of the dorsal column lesion and the amount of cortical reactivation has not been clear. ...

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1. Several features of the two complete and separate representations of the contralateral body surface in cortical areas 3b and 1 of somatosensory cortex in owl monkeys were quantitatively studied. 2. Area1 magnification factors for different body regions in the two representations were obtained. The glabrous hand and foot regions were found to occupy nearly 100 times more cortical tissue per u...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2012

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1121604109