Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling
نویسندگان
چکیده
منابع مشابه
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling
Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the branch point of these pathways. Here, we show that cholesterol sele...
متن کاملNon-canonical Wnt signalling and regulation of gastrulation movements.
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrul...
متن کاملJB Review Non-canonical WNT signalling in the lung
Department of Pediatrics, Division of Newborn Medicine, Los Angeles County+University of Southern California Medical Center and Children’s Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA 90033, USA; Excellence Cluster CardioPulmonary System (ECCPS), D-35392 Giessen, Hessen, Germany; Member of the German Center for Lung Research, Department of Internal Medicine II, Universi...
متن کاملAgonistic and Antagonistic Roles for TNIK and MINK in Non-Canonical and Canonical Wnt Signalling
Wnt signalling is a key regulatory factor in animal development and homeostasis and plays an important role in the establishment and progression of cancer. Wnt signals are predominantly transduced via the Frizzled family of serpentine receptors to two distinct pathways, the canonical ß-catenin pathway and a non-canonical pathway controlling planar cell polarity and convergent extension. Interfe...
متن کاملSulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling
Wnt signalling plays essential roles during embryonic development and is known to be mis-regulated in human disease. There are many molecular mechanisms that ensure tight regulation of Wnt activity. One such regulator is the heparan-sulfate-specific 6-O-endosulfatase Sulf1. Sulf1 acts extracellularly to modify the structure of heparan sulfate chains to affect the bio-availability of Wnt ligands...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms5393