Chloroquine reduces urinary excretion of cloxacillin when it is administered concurrently with ampicillin-cloxacillin combination
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چکیده
منابع مشابه
Significant Pharmacokinetic Interactions Between Quinine and Ampicillin–Cloxacillin Combination
INTRODUCTION The co-existence of malaria with bacterial infections is common in the tropics, hence the concurrent use of antimalarials and antibiotics. OBJECTIVE This study aimed to investigate the effect on pharmacokinetics and antimicrobial activity of co-administration of quinine and combined ampicillin-cloxacillin. METHODS In total, 14 healthy adults received single oral doses of ampici...
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Synergistic antibacterial effects of mixtures of ampicillin and cloxacillin and induced penicillinases were investigated in 48 strains of Proteus. The serial tube dilution method was used to determine the minimal inhibitory concentration of ampicillin, cloxacillin, and 2:1 and 1:1 mixtures of ampicillin and cloxacillin. Production of penicillinases was determined by the cellulose acetate membra...
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Urinary excretion data were obtained after oral administration of a single dose of 250 mg of Cloxacillin in six healthy young men volunteers. The excretion rate data were fitted to single and two compartment open models and the pharmacokinetic parameters were determined. The drug showed a rapid absorption and fast distribution. The time of appearance of peak renal excretion was 45 minutes in al...
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The spectrophotometric and microbiological assay methods used for the determination of ampicillin levels in ampicillin/cloxacillin combinations were compared. A total of 24 samples of ampicillin/cloxacillin suspensions from 8 batches and 3 companies (B2, D and E) were assayed for their ampicillin content levels using the Spectrophotometric assay method. Infra-red (IR) Spectroscopy confirmed the...
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Fifty bacterial isolates comprising Staphylococcus aureusand Staphylococcus albusfrom six pathological sources were exposed to honey and its fractional dilutions as also as to two standard antibiotics - cloxacillin (5 mg/ml) and ampicillin (10 mg/ml) - in an agar-cup diffusion sensitivity test. The undiluted honey showed antibacterial activity against almost 100% of the bacterial isolates while...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2003
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v2i1.14582