Chloroquine: Protection Against Virus-induced Cell Damage Without Inhibition of Virus Growth

Chloroquine: protection against virus-induced cell damage without inhibition of virus growth.

Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters

The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.

Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis.

Chronic hepatitis C virus (HCV) infection results in progressive liver fibrosis leading to cirrhosis and liver cancer. The mechanism for this remains unclear but hepatocyte apoptosis is thought to play a major role. Hepatocyte apoptosis in human liver tissue was determined by immunohistochemistry for cytokeratin 18 (M30 CytoDEATH) and cleaved poly(ADP-ribose) polymerase (PARP). In vitro studies...

Problems of protection against virus B hepatitis.

Various methods have been employed to reduce hepatitis B infections among patients and staff at high risk. Routine screening tests of all blood donors for hepatitis B surface antigen has reduced post-transfusion hepatitis B. After a control and prevention programme was instituted hepatitis B cross-infection was eliminated from haemodialysis units in Britain. Prophylaxis with specific immunoglob...

Level of respiratory protection against influenza virus

Sir, the recent report on influenza is very interesting [1]. Heuer et al. reported that “The three tested filters retained the virus input, indicating that their use in the breathing systems of intubated and mechanically ventilated patients can reduce the risk of spreading the virus to the breathing system and the ambient air." [1] In fact, the management of the intubation in the era of influen...