منابع مشابه
Chloroquine-induced Pruritus
Chloroquine-induced pruritus remains one of the most common side-effects in the use of chloroquine in the prophylaxis and treatment of uncomplicated malaria before the advent of artemisinin-based combination therapies. It has been reported to vary from a tolerable to intolerable intensity among susceptible individuals resulting in disruption of treatment and development of resistance to the dru...
متن کاملFactors associated with chloroquine-induced pruritus during malaria treatment in Mozambican university students.
INTRODUCTION It has been suggested that reductions in chloroquine use may be followed by a resurgence of chloroquine-susceptible falciparum malaria, and chloroquine might once again be an effective treatment choice, which renews the importance of aspects related to its use and misuse. Therefore, we aimed to estimate the prevalence of chloroquine-induced pruritus and to identify risk factors for...
متن کاملSensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus
The cellular and molecular mechanisms mediating histamine-independent itch in primary sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side effect of this widely used antimalarial drug. Here, we show that Mrgprs, a family of G protein-coupled receptors expressed exclusively in peripheral sensory neurons, function as itch receptors. Mice lacking a cluster of Mrgp...
متن کاملCharacterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of pruritus are needed to support the development of new drugs. Induction of pruritus by chloroquine (CQ) in mice is widely used, although, as with similar models, it has low throughput and does not distinguish between antipruritic effects a...
متن کاملHydroxychloroquine-induced pruritus.
Sir, Hydroxychloroquine is a derivative of chloroquine and is frequently used in dermatological practice in the management of a number of conditions including photosensitivity disorders. There are a number of recorded side-e¡ects of this therapy. Pruritus is a well recognized side-e¡ect of chloroquine treatment of malaria in Africans and has also, rarely, been reported in Caucasians. To our kno...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2010
ISSN: 0250-474X
DOI: 10.4103/0250-474x.70471