Chloroquine, an Antifungal but Also a Fertility Drug

Simon V . Avery Farida Islahudin , Kang - Nee Ting , Richard J . Pleass and Also a Fertility Drug ' ' Reply to ' ' Chloroquine , an Antifungal

Evolution-Based Drug Discovery: Antifungal Also Disrupts Blood Vessel Formation

Mice, frogs, and even yeast are useful in research in large part because they share so many of our genes. And as a surge of genetic data has become available in recent years, scientists have realized that not just individual genes but entire genetic pathways are often conserved across disparate organisms. In some cases, a genetic module doesn’t serve an identical purpose across species; rather,...

Lamisil, a potent alternative antifungal drug for otomycosis

Background and Purpose: Otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal caused mainly by several species of saprophytic fungi. Lamisil (Terbinafine) is an allylamine antifungal agent, that is used both in the topical and oral administration for the treatment of dermatophytosis, cutaneous candidiasis, and the pityriasis ve...

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles.

Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofung...

Antifungal drug resistance.

The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term treatment or who are receiving antifungal pr...