CHLORMETHINE (C) IN NEPHROSIS (N)

A.C.T.H. in nephrosis.

During the past two years 16 cases of nephrosis have been treated with cortisone and/or A.C.T.H. (adrenocorticotrophin) at this hospital. The results of cortisone treatment have been reported previously (Arneil and Wilson, 1952) and corresponding findings for A.C.T.H. are now given and the value of the two hormones compared. The criteria used when including a patient in this investigation and t...

Aminonucleoside Nephrosis

Experimental renal disease was produced in young rats by daily subcutaneous injections of 6-dimethylamino purine, 3-amino-d-ribose (aminonucleoside). The physiologic, biochemical, and light microscopic changes were similar to those observed in human nephrosis. Electron microscopy of the glomeruli from animals which received seven or more daily injections of aminonucleoside revealed characterist...

Immunological studies in congenital nephrosis.

Lipoprotein metabolism in experimental nephrosis.

In experimental nephrosis, a decrease in plasma albumin resulting from proteinuria causes a decreased in the plasma oncotic pressure. The existence of an osmoreceptor, which responds to the low oncotic pressure and produces a factor(s) that signals the liver to increase the secretion of plasma proteins, is postulated. The hyperlipidemia characteristic of the nephrotic syndrome results primarily...

Hetastarch-induced osmotic nephrosis.

A 63-YR-OLD male (weighing approximately 83 kg) with no significant past medical history underwent an open reduction and internal fixation of his femur fracture under general anesthesia. He had been nil per os for 14 h and his preoperative blood pressure was 136/74 mmHg. Intraoperative course was uneventful, except for a 5–7 min episode of relative hypotension with systolic pressures 80 – 85 mm...