منابع مشابه
Chlorambucil-Induced Acute Interstitial Pneumonitis
Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. The interstitial pneumonitis responded to therapy with prednisone. We performed a systematic review of literature and identified 13 other case re...
متن کاملFocal fits during chlorambucil therapy.
Introduction Chronic lymphatic leukaemia is a disease of the elderly with a long natural history. Treatment is palliative, with chlorambucil the drug of choice (Livingston and Carter, 1970). The recognized side effects of chlorambucil include nausea, myelosuppression, skin eruptions and pulmonary fibrosis (Stenfert Kroese, 1975), but their incidence is low. Although high doses of chlorambucil a...
متن کاملRapid desensitization for chlorambucil drug fever.
Chlorambucil is an oral alkylating agent, introduced in 1953, that is still used as a primary treatment for chronic lymphocytic leukemia (CLL). Chlorambucil is usually well tolerated and often administered intermittently, with intervals of months or years between recurrent courses of treatment. Chlorambucil-induced drug fever presents as fever, rigors, and malaise within hours to days of starti...
متن کاملTheophylline Synergizes With Chlorambucil in Inducing Apoptosis
We tested the effects of theophylline, a phosphodiesterase inhibitor inducing intracellular accumulation of cyclic adenosine monophosphate (CAMPI, on malignant B cells from 15 patients with B-chronic lymphocytic leukemia (B-CLL). We observed a large increase in apoptotic cell numbers (mean, 90% ~ 2 0 % in medium alone) in the presence of theophylline (100 pglmL) or chlorambucil (10 pmollL) afte...
متن کاملTreatment of Behcet's disease with chlorambucil.
Five patients with Behcet's disease in the active and progressive stages were treated with chlorambucil (Leukeran). In all aptients a long-lasting remission was obtained, the ocular lesions did not progress and the vision did not deteriorate. Follow-up varied between 10 and 24 months. Results were encouraging and the form of treatment with chlorambucil and small doses of corticosteroids was sup...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1972
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5831.52-a