منابع مشابه
What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?
The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported increased bone marrow vascularity and elevation of angiogenic cytokines in acute lymphoblastic leukaemia (ALL). VEGF and basic fibroblast growth factor (bFGF...
متن کاملVariable detection of myeloid antigens in childhood acute lymphoblastic leukaemia.
AIMS To determine whether the use of different sources of anti-CD13 and anti-CD33 monoclonal antibodies leads to discrepant results in childhood acute lymphoblastic leukaemia (ALL), which might contribute to the wide variation in the reported incidence of myeloid antigen expressing ALL in childhood. METHODS Stored leukaemic cells from 10 children with previously defined myeloid positive ALL w...
متن کاملBone marrow fibrosis in acute lymphoblastic leukaemia of childhood.
A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary myelofibrosis (SMF) was present at diagnosis in 57% of the cases. It was not statistically significantly related to the prognosis or course of the disease. Thus, although trephine biopsy occasionally provid...
متن کاملHypercalcaemia: an unusual presenting feature of childhood acute lymphoblastic leukaemia.
A 3-year-old boy was referred for management of severe symptomatic hypercalcaemia. His parents reported increasing lower limb pain and weakness over the preceding 4 months. Examination indicated a bedbound, pale, irritable child with generalized bony tenderness and peripheral lymphadenopathy; there were no palpable abdominal masses. The serum calcium was 5 3 mmol/l; serum phosphate, alkaline ph...
متن کاملMorphological heterogeneity in childhood B cell acute lymphoblastic leukaemia.
Considerable heterogeneity of lymphoblast morphology in childhood B cell acute lymphoblastic leukaemia has been observed. One case showed unusual monocytic features and emphasised the need for marker studies in the accurate definition of acute lymphoblastic leukaemia phenotypes. B cell acute lymphoblastic leukaemia is rare but may have been previously underestimated by morphological misinterpre...
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ژورنال
عنوان ژورنال: Morecambe Bay Medical Journal
سال: 2013
ISSN: 2634-0631,0957-5286
DOI: 10.48037/mbmj.v6i10.222