Chikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspective

Chikungunya virus: emerging targets and new opportunities for medicinal chemistry.

Chikungunya virus is an emerging arbovirus that is widespread in tropical regions and is spreading quickly to temperate climates with recent epidemics in Africa and Asia and documented outbreaks in Europe and the Americas. It is having an increasingly major impact on humankind, with potentially life-threatening and debilitating arthritis. There is no treatment available, and only in the past 24...

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes chikungunya fever

Development of a Pseudotyped Lentiviral Vector–Based Neutralization Assay for 1 Chikungunya Virus Infection 2 3 Running Title: CHIKV-pseudotyped lentiviral vector–based NT assay 4 5 Natsuko Kishishita, Naokazu Takeda, Atchareeya Anuegoonpipat, and Surapee 6 Anantapreecha 7 8 Thailand-Japan Research Collaboration Center on Emerging and Reemerging Infections 9 (RCC-ERI), Nonthaburi, Thailand 10 R...

Why Can We See a Local Spread of Chikungunya Virus (CHIKV) Infection?

Challenges in Surveillance for Chikungunya Virus (CHIKV) Infection

Introduction CHIKV is transmitted by mosquitoes and often occurs in large outbreaks with high attack rates. Common symptoms (which can be severe and disabling) include fever, joint pain/swelling, headache, muscle pain and rash. In December 2013, the World Health Organization reported local CHIKV transmission in the Caribbean. In July 2014, the first locally-acquired case in the continental U.S....

Molecular Shape and Medicinal Chemistry: A Perspective

The eight contributions here provide ample evidence that shape as a volume or as a surface is a vibrant and useful concept when applied to drug discovery. It provides a reliable scaffold for "decoration" with chemical intuition (or bias) for virtual screening and lead optimization but also has its unadorned uses, as in library design, ligand fitting, pose prediction, or active site description....