CHEMOTHERAPEUTIC STUDIES ON ORGANIC COMPOUNDS CONTAINING MERCURY AND ARSENIC

Determination of chlorine in organic compounds containing mercury

The standard procedure for the determination of chlorine in organic compounds of mercury consists in decomposition of the material, separation of mercury and determination of chlorine as chloride. Decomposition of the sample could be achieved by wet mineralization [1,2], ignition in a stream of oxygen [3—7] or nitrogen [8], ignition in a flask with oxygen [9], etc. [10, 11]. Chlorine and mercur...

Organic mercury compounds and autoimmunity.

Based on in vitro studies and short-term in vivo studies, all mercurials were for a long time considered as prototypic immunosuppressive substances. Recent studies have confirmed that organic mercurials such as methyl mercury (MeHg) and ethyl mercury (EtHg) are much more potent immunosuppressors than inorganic mercury (Hg). However, Hg interacts with the immune system in the presence of a susce...

ORGANIC CHEMISTRY Organic Compounds containing Nitrogen

Studies on structure-diuretic activity relationships of organic compounds of mercury.

According to Friedman ( 1 ), the nature of the X substituent (usually halogen, theophylline or thioglycolate) has no effect on diuretic potency if the compound is given intravenously, but does influence both hyperacute (cardiac and respiratory arrest) and acute (7 to 14-day) renal toxicity. The nature of the OY group is determined by the solvent in which the mercuration is carried out and is an...

Some nitrogen and sulfur containing compounds as chemotherapeutic agents.