منابع مشابه
Chemokines, lymphocytes, and HIV.
Chemokines are members of a family of more than 30 human cytokines whose best-described activities are as chemotactic factors for leukocytes and that are presumed to be important in leukocyte recruitment and trafficking. While many chemokines can act on lymphocytes, the roles of chemokines and their receptors in lymphocyte biology are poorly understood. The recent discoveries that chemokines ca...
متن کاملT lymphocytes to chemokines
Two subpopulations of human T lymphocytes expressing different antigen receptors, § / g and + / ˇ , emigrate into inflamed tissues in distinctive patterns. We compared the transmigration of § / g and + / ˇ T cells to C-C and C-X-C chemokines using an in vitro transendothelial chemotaxis assay. The C-C chemokines monocyte chemoattractant protein (MCP)-1, RANTES, macrophage inflammatory protein (...
متن کاملAntigen–specific release of β-chemokines by anti-HIV-1 cytotoxic T lymphocytes
A major advance in understanding human immunodeficiency virus (HIV) biology was the discovery that the b-chemokines MIP-1a (macrophage inflammatory protein-1a), MIP-1b (macrophage inflammatory protein-1b) and RANTES (regulated on activation, normal T-cell expressed and secreted) inhibit entry of HIV-1 into CD4+ cells by blocking the critical interaction between the CCR5 coreceptor and the V3 do...
متن کاملChemokines and HIV: The First Close Encounter
The first “close encounter” between the fields of chemokines and HIV occurred in the late spring of 1995, when my group at NCI’s Laboratory of Tumor Cell Biology (LTCB) received from Harvard Microchemistry and Proteomics the amino acid sequences of three peptide fragments from an HPLC-purified fraction that we had submitted a few weeks earlier. The sequences showed a perfect match with the huma...
متن کاملChemokines and the tissue-specific migration of lymphocytes.
Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights an important role for epithelial cells in controlling homeostatic lymphocyte tr...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 1998
ISSN: 0100-879X
DOI: 10.1590/s0100-879x1998000100002