منابع مشابه
Epithelial cancer cell migration: a role for chemokine receptors?
We investigated the possibility that chemokine gradients influence migration of human ovarian epithelial tumor cells. Of 14 chemokine receptors investigated, only CXCR4 was expressed on ovarian cancer cells. CXCR4 mRNA localized to a subpopulation of tumor cells in ovarian cancer biopsies. Ovarian cancer cell lines and cells freshly isolated from ascites expressed CXCR4 protein. The CXCR4 ligan...
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Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. Cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. In this study, we examine...
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Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...
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Objective(s):The limited homing potential of bone-marrow-derived mesenchymal stem cells (BM-MSC) is the key obstacle in MSC-based therapy. It is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. Meanwhile, MSCs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...
متن کاملChemokine receptors and T cell chemotaxis
T he migration of T cells is a highly regulated process, serving to distribute functional subsets of cells to the appropriate tissue or microenvironment. The role of adhesion molecules in this process is well appreciated (1, 2) however an additional class of molecules, the chemoattrac-tant cytokines (chemokines) and their receptors, are now receiving considerable attention, because of their fun...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2019
ISSN: 0915-7441,1880-8808
DOI: 10.2491/jjsth.30.610