منابع مشابه
Net sequence gazing
Last month, The spider's web looked at the range of biological resources available on the net. This month there are more specific tips on how to get the most out of these tools, for the least effort, with an emphasis on tools for sequence analysis. As is true of almost any use of computers, getting something done on the net requires a lot of non-intuitive knowledge, and net knowledge becomes re...
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Elucidating the mechanism of folding of polynucleotides depends on accurate estimates of free energy surfaces and a quantitative description of the kinetics of structure formation. Here, the kinetics of hairpin formation in single-stranded DNA are measured after a laser temperature jump. The kinetics are modeled as configurational diffusion on a free energy surface obtained from a statistical m...
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This paper introduces a systematic approach to organizing the discipline of clinical chemistry. The approach is called a top-down systems approach because it starts at the top with the most general concepts and works down through less general concepts to the most specific details and techniques. The hypothesis is that the discipline can be organized into hierarchical levels of functional proces...
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re chromosomes distributed randomly within the cell nucleus during interphase, or do they preferentially cluster into specific groups? On page 237, Cornforth et al. address this question, which has been debated vigorously for nearly a century, and conclude that the distribution of chromosomes within the nucleus of human cells is mostly, but not entirely, random. The work provides the most compr...
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thinking to clarify complex problems. My introduction to Tilney’s Listeria papers came when I sought a post-doctoral position with Daniel Louvard at the Institut Pasteur in Paris. I had previously studied mitosis and wanted to learn about the behaviour of the actin cytoskeleton during mitosis, in particular at cytokinesis. I was directed to Louvard’s associate, Evelyne Friederich, who had recen...
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ژورنال
عنوان ژورنال: Science
سال: 2008
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.320.5875.426c