Chemistry and pharmacology of anticancer drugs

Hepatobiliary transporters in the pharmacology and toxicology of anticancer drugs.

The existence of carrier proteins located in the basolateral and apical membranes of hepatocytes, cholangiocytes and epithelial cells of the ileal mucosa, together with their more or less broad substrate specificities -implying their ability to transport many different drugs, including anticancer drugs- has important pharmacological repercussions. These vary from the existence of interactions o...

Chemistry, pharmacology, and metabolism of emerging drugs of abuse.

In recent years, besides the classic designer drugs of the amphetamine type, a series of new drug classes appeared on the illicit drugs market. The chemistry, pharmacology, toxicology, metabolism, and toxicokinetics is discussed of 2,5-dimethoxy amphetamines, 2,5-dimethoxy phenethylamines, beta-keto-amphetamines, phencyclidine derivatives as well as of herbal drugs, ie, Kratom. They have gained...

Drugs of Abuse: Chemistry, Pharmacology, Immunology, and AIDS, 96

Natural Based Anticancer Drugs and Their Worthiness

Chemistry and pharmacology of benzodioxanes

Benzodioxane represents a series of synthetic and natural compounds of considerable medicinal importance. Compounds containing dioxane ring systems exhibited different biological activities such as antihepatotoxic, -adrenergic blocking agent, neuroleptic, anti-inflammatory, hypolipidemic and D 2 antagonist/5-HT 1A partial agonist activity. The literature concerning chemistry of benzodioxanes c...