Chemically cross?linked poly(vinyl alcohol) electrospun fibrous mats as wound dressing materials

BACKGROUND Poly(vinyl alcohol) (PVA) is a synthetic biocompatible polymer that extensively used by the medical and pharmaceutical industries due to its FDA approval for in vivo applications. Its highly hydrophilic nature makes it an ideal wound dressing material, especially form of nanofibrous mats. RESULTS In this work, electrospun PVA-based scaffolds suitable management were created. Chemical cross-linking with citric acid glyoxal was employed enhance supports’ stability aqueous environments, cellulose nanocrystals added during electrospinning process improve mechanical properties final constructs. Varying concentrations agents (0.12-1 wt% 0.06-0.5 glyoxal), allowed control rate extend dissolution, thereby tuning materials specific types (e.g. acute vs chronic). There inverse relationship between amount cross-linkers mats’ weight loss (ranging from 2% 18%) after 6 days immersion water. All supports sustained growth human fibroblasts (>85% viability), whereas there no biofilm formation when contact S. aureus 24 hours. The presence did not affect cytocompatibility but improved non-woven fibres. CONCLUSION Tailor-made mats showing antimicrobial behaviour successfully created through altering concentration chemical cross-linkers. This flexible approach offers potential matching type offering more targeted solution management. © 2021 Society Industry (SCI).