Chemical Studies on Tuberculin

Studies on Tuberculin Fever

In a search for the source of the circulating endogenous pyrogen (EP) that mediates tuberculin-induced fever, tuberculin was incubated in vitro with various tissues of rabbits sensitized by intravenous infection with BCG. Evidence was obtained that tuberculin specifically stimulates cells in the blood of sensitized rabbits to generate pyrogen in vitro, whereas both lymph node and spleen cells f...

Further Studies on the Ophthalmo-tuberculin Reaction in Cattle

Our conclusions differ in a few points from those of our first work on this subject. We are able to sum up our observations in this series of experiments as follows: 1. The ophthalmo-tuberculin test is of limited value in the diagnosis of tuberculosis in cattle. In some cases the reaction is very slight (hyperaemia). In others more pronounced congestion with profuse exudates are noted. Accuracy...

Studies on the modification of Dorset - Henly medium for the producrtion of bovine tuberculin

Chemical biology studies on norrisolide.

The cellular activity of norrisolide (7), a novel Golgi-vesiculating agent, was dissected as function of its chemical structure. This natural product induces irreversible vesiculation of the Golgi membranes and blocks protein transport at the level of the Golgi. The Golgi localization and fragmentation effects of 7 depend on the presence of the perhydroindane core, while the irreversibility of ...

Chemical Studies on Sludge Digestion