Chemical studies of some fused heterocyclic compounds containing oxygen with anticipated biological interests: Thesis Abstract

Thesis AbstractBackground: Heterocyclic are known to have multiple applications in particular biomedical settings. Aim: The present study reports a convenient protocol for the design and synthesis of new heterocyclic compounds incorporating 1- hydroxy-naphthyl angular chromones bearing allylnaphthyl fragments. Materials Methods: versatile precursor 2-acetyl-4- allyl-1-hydroxy naphthalene was subjected Claisen-Schmidt condensation but 6-allyl-3-formyl-4H-benzo[h]chromone prepared via Vilsmeier–Haack reaction 4-allyl-1- hydroxy-2-acetonaphthone. Results: Some considered as promising leads with dual biological activity antibacterial antioxidant. isoalloxazine ring cofactor FAD is essential recognition compound that has proper antioxidant activity. Benzocoumarin amino acid residues. Allyl chain improves p stacking interaction while n-propyl attenuates overall interaction. Naphthyl needs be substituted short bridge avid extended away from pocket. antimicrobial antiquorum-sensing activities newly synthesized showed many good comparison reference drugs. Conclusion: Based on computational prediction pharmacokinetics, drug-likeness properties, activity, molecular docking suggested formyl chromone tetracarbonyl may potent drugs