Chemical properties of bile acids. IV. Acidity constants of glycine-conjugated bile acids.
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چکیده
منابع مشابه
Chemical properties of bile acids. IV. Acidity constants of glycine-conjugated bile acids.
The dissociation constants for the carboxyl group of a series of glycine (N-acyl)-conjugated and unconjugated bile acids were determined by potentiometric titration using dimethylsulfoxide-water and methanol-water mixtures of varying proportions. The pKa values in water were calculated by extrapolating the experimental values determined in different mole fractions of the organic solvent mixture...
متن کاملMetabolism of steroid and amino acid moieties of conjugated bile acids in man. II. Glycine-conjugated dihydroxy bile acids.
Chenodeoxycholyl-2,4-(3)H-glycine-1-(14)C and deoxycholyl-2,4-(3)H-glycine-1-(14)C were synthesized and administered orally to 10 healthy subjects. Distribution of radioactivity among bile acids and specific activity of steroid and amino acid moieties were determined in bile samples. (3)H and (14)C were measured in feces. (14)C in breath was calculated from interval (14)CO(2) specific activity ...
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Ileal disease, liver disease, and other pathologic conditions have been shown to affect the glycine:taurine ratio (1). The procedure used for determining the glycine:taurine ratio is to separate the individual conjugated bile acids on thin-layer chromatograms and estimate the quantities of each bile acid to get the ratio (2, 3). Sometimes two or more solvent systems are needed to separate the i...
متن کاملDetermination of individual conjugated bile acids in human bile.
A method has been developed and validated for the determination of the six major conjugated bile acids, cholesterol, and total phospholipids in bile of human subjects previously injected with 4-(14)C-cholesterol. The procedure is designed for use with 5-10 ml of duodenal or T-tube bile and eliminates difficulties associated with existing methods for bile acid determination, in particular the re...
متن کاملA Synthesis of Conjugated Bile Acids
In 1916 Wieland and Sorge (1) first described the formation of addition compounds of desoxycholic acid with fatty acids, and suggested the possible importance of this “choleic acid principle” in furthering the absorption of fatty acids and other substances from the intestinal canal. In human bile, however, desoxycholic acid is united with glycine and taurine; hence it is of considerable importa...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1987
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)38646-6