Chemical kinomics: a powerful strategy for target deconvolution

Chemical kinomics: a powerful strategy for target deconvolution.

Kinomics is an emerging and promising approach for deciphering kinomes. Chemical kinomics is a discipline of chemical genomics that is also referred to as "chemogenomics", which is derived from chemistry and biology. Chemical kinomics has become a powerful approach to decipher complicated phosphorylation-based cellular signaling networks with the aid of small molecules that modulate kinase func...

A Powerful Evaluation Strategy For CLP Programs

This paper presents a new, powerful evaluation strategy (OLDTC-AM) for CLP programs. OLDTC-AM is developed by combining the OLDT evaluation strategy with a logical answer manipulation mechanism. Under the OLDTC-AM evaluation strategy, the termination characteristics of CLP programs are greatly improved and the expressive abilities of CLP languages are greatly increased. One application of this ...

A Powerful Chiral Counterion Strategy

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affinity based target deconvolution of safranal

Exploiting polypharmacology for drug target deconvolution.

Polypharmacology (action of drugs against multiple targets) represents a tempting avenue for new drug development; unfortunately, methods capable of exploiting the known polypharmacology of drugs for target deconvolution are lacking. Here, we present an ensemble approach using elastic net regularization combined with mRNA expression profiling and previously characterized data on a large set of ...