Chemical Compounds as Carcinogenic Agents

Chemical Compounds as Carcinogenic Agents

A review of the progress made in the study of the carcinogenic properties of chemical compounds, incorporating literature published during the triennial period between the First and Second International Cancer Congresses, was presented to the Second International Congress in Brussels, in September 1936, and was subsequently reprinted with an addendum covering most of the literature published up...

Carcinogenic Chemical Agents *

Cancer is a disease which has long been shrouded in mystery, but our knowledge of its intricacies has been extended in numerous directions by investigations carried on in all parts of the world by workers in many branches of science. Yet it remains true that in general we are not able to explain the origin of cancer, and the methods of treatment at present available are pitifully inadequate. Th...

Physical and chemical agents and carcinogenic risk.

Specific crystal chemical interactions between carcinogenic aromatic compounds and cholesterol.

Polycyclic aromatic hydrocarbons and aromatic amines exercise a highly specific influence on the crystallization of cholesterol. The strength of these non-covalent, presumably epitaxial interactions correlates with the carcinogenic activity of these substances. The presented results are in support of the assumption that a specific process of adsorption and crystallization with cholesterol of th...

Statistical Modeling and Prediction of Carcinogenic Activity of Chemical Compounds

We have established two classification rules that statistically accurate allow to separate carcinogenically active chemical compounds from inactive chemical compounds. The electronic and information properties of molecules are used as molecular descriptors. The threshold values of descriptors that characterize and determine the presence or absence of carcinogenic properties of chemical compound...