منابع مشابه
Chelating agents in biological systems.
Chelation enables metals to be transported to or from vulnerable target sites, and to hinder or facilitate their carcinogenic potential. In the reverse sense, metals are capable of ligand scavenging via complexation or mixed complex formation--the latter being the result of interaction with binary complexes. Consequently, metal complexes can be utilized for the transport of selected organic che...
متن کاملBiological activities of pyochelins: iron-chelating agents of Pseudomonas aeruginosa.
Strains of Pseudomonas aeruginosa able to grow readily in serum (serum resistant) produce siderophores in large quantity, enabling them to extract iron from transferrins. The term pyochelin has been proposed for this group of compounds. Pyochelin extractable with ethyl acetate and designated pyochelin A appears to be a mixture of catechols and other phenolates. The structures of water-soluble s...
متن کاملCooperativity in biological systems
Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...
متن کاملDesign of therapeutic chelating agents.
The successful design of orally active non-toxic selective metal chelators is a much sought-after goal. In order to identify an ideal chelator for clinical use, a range of specifications must be considered, such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. In this overview the comparative properties of ligands capable of endowing complexes w...
متن کاملSynthetic chelating agents in iron metabolism.
Iron in man is held within the cells incorporated in organic complex molecules, either as functional iron, i.e., hemoglobin and tissue enzymes, or as storage iron, i.e., ferritin and hemosiderin. Owing to the requirements of the erythroid marrow in particular, large amounts of iron must constantly pass from one cell to another through the plasma. This plasma transport is brought about by a #3gl...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1981
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.8140227