Checks and balances: E2F—microRNA crosstalk in cancer control
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Checks and Balances in Neuromodulation
Neuromodulators such as monoamines and peptides play important roles in activating and reconfiguring neural networks to allow behavioral flexibility. While the net effects of a neuromodulator change the network in a particular direction, careful studies of modulatory effects reveal multiple cases where a neuromodulator will activate functionally opposing mechanisms on a single neuron or synapse...
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Age-associated changes in the immune system including alterations in surface protein expression are thought to contribute to an increased susceptibility for autoimmune diseases. The balance between the expression of coinhibitory and costimulatory surface protein molecules, also known as immune checkpoint molecules, is crucial in fine-tuning the immune response and preventing autoimmunity. The a...
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betrayal of the innocents, " announced the Daily Mail. The outrage expressed in Britain's newspapers on 31 January, amplified further through radio and television, lasted several days. It was triggered by the publication of findings from an inquiry into the retention of organs after necropsy at the Royal Liverpool Children's Hospital, Alder Hey. The report concluded that over 2,000 organs had b...
متن کاملChecks and balances for the iron bank.
The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase component FBXL5. However, the mechanisms for coordination between Fe-S cluster assembly, FBXL5, and IRP1/IRP2 activity are poorly defined. A new study reveals that FBXL5 plays a critical role in limiting IRP1 and IRP2 overaccumulation when cyto...
متن کامل" Checks and Balances " in the identification of Symbiodinium genetic diversity
The identification of genetic diversity in dinoflagellates belonging to the genus Symbiodinium has been the subject of numerous studies over the last decade. During this time, a variety of molecules have been utilized. Some of these loci offer a "coarse" (i.e., 18S-rDNA) view while others provide a much "finer" (i.e., DNA fingerprinting) portrait of diversity within Symbiodinium. The use of seq...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.13.12061