Characterizing effects of HB-EGF on H1N1 infection in mice

نویسندگان

چکیده

Abstract Heparin-Binding EGF-like Growth Factor (HB-EGF) is a ligand for the Epidermal Receptor (EGFR), tyrosine kinase receptor which promotes cell proliferation and migration. In epithelium of lung, HB-EGF an important factor wound repair, however little known about effects on viral infection in vivo. Literature suggests that human alveolar epithelial lines, EGFR cofactor Influenza A infection, treatment with decreases both M1 protein cells. We use mouse model to examine this our model, we HBEGFff/Lyz2Cre knock out myeloid cells infect adapted H1N1 influenza virus. then harvest lungs day 5 analyze RNA transcripts by qPCR. expected see increased polymerase transcript KO mice. saw increase male mice initial experiment, but not females. plan repeat experiment changes immunological milieu between HB-EGFff controls, males Supported grant from NIH Postbaccalaureate Research Education Program (PREP) (R25)

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ژورنال

عنوان ژورنال: Journal of Immunology

سال: 2023

ISSN: ['1550-6606', '0022-1767']

DOI: https://doi.org/10.4049/jimmunol.210.supp.235.37