Characterization of TRIM5α trimerization and its contribution to human immunodeficiency virus capsid binding
نویسندگان
چکیده
منابع مشابه
The Carboxyl-Terminus of Human Immunodeficiency Virus Type 2 Circulating Recombinant form 01_AB Capsid Protein Affects Sensitivity to Human TRIM5α
Human immunodeficiency virus (HIV) type 2 shows limited geographical distribution compared with HIV type 1. Although 8 genetic groups of HIV type 2 (HIV-2) have been described, recombinant viruses between these groups are rarely observed. Recently, three HIV-2 patients in Japan were described with rapidly progressive, acquired immunodeficiency. These patients were infected with an A/B inter-gro...
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UNLABELLED Following human immunodeficiency virus type 1 (HIV-1) entry into the host cell, the viral capsid gradually disassembles in a process called uncoating. A proper rate of uncoating is important for reverse transcription of the HIV-1 genome. Host restriction factors such as TRIM5α and TRIMCyp bind retroviral capsids and cause premature disassembly, leading to blocks in reverse transcript...
متن کاملContribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid
Following human immunodeficiency virus (HIV-1) entry into the host cell, the viral capsid gradually disassembles in a process called uncoating. A proper rate of uncoating is important for reverse transcription of the HIV-1 genome. Host restriction factors such as TRIM5α and TRIMCyp bind retroviral capsids and cause premature disassembly, leading to blocks in reverse transcription. Other host fa...
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The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, mediates binding to the viral receptors and, along with the transmembrane glycoprotein gp41, is a major target for neutralizing antibodies. We asked whether replacing the gp41 fusion/trimerization domain with a stable trimerization motif might lead to a more stable gp120 trimer that would be amenable to struc...
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The human immunodeficiency virus (HIV) is lentivirus (subgroup of retrovirus) which causes HIV infection and it acquired immunodeficiency syndrome (AIDS). HIV infection leads to low levels of CD4+T cells through number of mechanisms [1]. Our purpose is to review educative HIV prevention and control as Millennium Development Goal (MDG) and WHO's operational goal. In 2000, when ...
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ژورنال
عنوان ژورنال: Virology
سال: 2006
ISSN: 0042-6822
DOI: 10.1016/j.virol.2006.05.017