Characterization of TP53 mutations in clonal cytopenia of undetermined significance
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چکیده
منابع مشابه
Idiopathic cytopenia of undetermined significance and systemic lupus erythematosus
DOI: 10.5581/1516-8484.20130068 Idiopathic cytopenia of undetermined significance (ICUS) is characterized as less than 10% of dysplasias with less than 5% blasts in the bone marrow, however, it may be present heterogeneously. Until the present, only a small number of cases have been published and knowledge about the mechanisms and prognosis is scarce(1). Systemic lupus erythematosus (SLE) is an...
متن کاملMyelodysplastic syndrome versus idiopathic cytopenia of undetermined significance: the role of morphology in distinguishing between these entities
DOI: 10.5581/1516-8484.20130069 Myelodysplastic syndrome (MDS) is a heterogeneous group of diseases characterized by ineffective and dysplastic hematopoiesis and pancytopenia in the peripheral blood(1). Minimal diagnostic criteria for MDS have been discussed by several working groups. The term idiopathic cytopenia of undetermined significance (ICUS) has been proposed to define patients who do n...
متن کاملDistinguishing myelodysplastic syndromes (MDS) from idiopathic cytopenia of undetermined significance (ICUS): HUMARA unravels clonality in a subgroup of patients.
BACKGROUND Patients not fulfilling minimal criteria for myelodysplastic syndromes (MDS) but presenting with persisting cytopenia(s) not attributable to a haematological or non-haematological disease are defined as 'idiopathic cytopenia of undetermined significance' (ICUS). DESIGN AND METHODS We retrospectively analysed 67 of 3504 patients from our MDS Registry fulfilling the criteria for ICUS...
متن کاملSignificance of TP53 mutations in human cancer: a critical analysis of mutations at CpG dinucleotides.
A detailed analysis of p53 (TP53) mutations involving the 42 CpG dinucleotides was performed to gain greater insight into the mutational mechanism leading to specific selection of these mutations. Although the majority of these CpG dinucleotides have been found to be mutated in cancer cells, the heterogeneous frequency of mutational events suggests that some mutations are not true mutations, bu...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2017
ISSN: 0361-8609
DOI: 10.1002/ajh.24786