Characterization of the myeloid-specific CD11b promoter
نویسندگان
چکیده
منابع مشابه
Characterization of the Myeloid - Specific C D l l b Promoter
The C D l l b/CD18 heterodimeric surface antigen is expressed exclusively on human monocytes, macrophages, granulocytes, and natural killer cells. During differentiation of myeloid cell lines, CDl lb steady state messenger RNA levels increase significantly; we show here that CDl lb transcription rates increase commensurately. A 1.7-kb fragment of C D l l b 5’ flanking sequence directs expressio...
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The CD11b (or macrophage-1 antigen; MAC-1) subunit of the leukocyte integrin family forms a noncovalently associated heterodimeric structure with the CD18 (beta) subunit on the surface of human granulocytes and monocyte/macrophages, where it enables these myeloid cells to participate in a variety of adherence-related activities. Expression of the CD11b subunit is restricted to cells of the myel...
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ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v79.4.865.bloodjournal794865