Characterization of the Meiosis‐Specific Recombinase Dmc1 ofPneumocystis
نویسندگان
چکیده
منابع مشابه
Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor suppression. RAD51AP1 (RAD51 associated protein 1) has been shown to interact with and enhance the recombinase activity of RAD51. Accordingly, genetic ablation of RAD51AP1 leads to enhanced sensitivity to and also chromosome aberrations upon DNA damage, demonstrating a role for RAD51AP1 in mitot...
متن کاملInteractions between human BRCA2 protein and the meiosis-specific recombinase DMC1.
Germline mutations in BRCA2 predispose to hereditary breast cancers. BRCA2 protein regulates recombinational repair by interaction with RAD51 via a series of degenerate BRC repeat motifs encoded by exon 11 (BRCA2(996-2113)), and an unrelated C-terminal domain (BRCA2(3265-3330)). BRCA2 is also required for meiotic recombination. Here, we show that human BRCA2 binds the meiosis-specific recombina...
متن کاملGenome wide cloning of maize meiotic recombinase Dmc1 and its functional structure through molecular phylogeny.
The development of meiotic division and associated genetic recombination paved the way for evolutionary changes. However, the secondary and tertiary structure and functional domains of many of the proteins involved in genetic recombination have not been studied in detail. We used the human Dmc1 gene product along with secondary and tertiary domain structures of Escherichia coli RecA protein to ...
متن کاملAberrant Sporogonic Development of Dmc1 (a Meiotic Recombinase) Deficient Plasmodium berghei Parasites
BACKGROUND In Plasmodium, meiosis occurs in diploid zygotes as they develop into haploid motile ookinetes inside the mosquito. Further sporogonic development involves transformation of ookinetes into oocysts and formation of infective sporozoites. METHODOLOGY/PRINCIPAL FINDINGS Reverse genetics was employed to examine the role of the meiotic specific recombinase Dmc1, a bacterial RecA homolog...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2010
ISSN: 0022-1899,1537-6613
DOI: 10.1086/657414