Characterization of the Human Transcobalamin II Promoter
نویسندگان
چکیده
منابع مشابه
The cloning and characterization of the human transcobalamin II gene.
Transcobalamin II (TCII) is a plasma protein that binds vitamin B12 (cobalamin; Cbl) and facilitates the cellular uptake of the vitamin by receptor-mediated endocytosis. In genetic disorders that are characterized by congenital deficiency of TCII, intracellular Cbl deficiency occurs, resulting in an early onset of megaloblastic anemia that is sometimes accompanied by a neurologic disorder. To d...
متن کاملThe cloning and characterization of the human transcobalamin II
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متن کاملThe Cloning and Characterization of the Human Transcobalamin I1 Gene
Transcobalamin II (TCII) is a plasma protein that binds vitamin B12 (cobalamin; Cbl) and facilitates the cellular uptake of the vitamin by receptor-mediated endocytosis. In genetic disorders that are characterized by congenital deficiency of TCII, intracellular Cbl deficiency occurs, resulting in an early onset of megaloblastic anemia that is sometimes accompanied by a neurologic disorder. To d...
متن کاملCharacterization of the receptor for transcobalamin II isolated from human placenta.
The receptor for transcobalamin II, the major plasma cobalamin (Cbl) transport protein, has been solubilized from human placenta with Triton X-100 and purified 40,000fold using affinity chromatography on rabbit transcobalamin II-Cbl-Sepharose as the major purification step. A major (70%) and two minor (15% each) forms of the receptor were distinguished in crude preparations using gel filtration...
متن کاملBone marrow participates in the biosynthesis of human transcobalamin II.
Studies concerning the site of synthesis of the vitamin B12 binding serum protein, transcobalamin II, have been done in various mammalian animals. The actual site of biosynthesis in man has not yet been defined. The finding that bone marrow derived cells release apo-transcobalamin II in the mouse led us to examine the genetic patterns of transcobalamin II in man, both before and after marrow tr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.26.16104