Characterization of Resistant Hypertension<subtitle>Association Between Resistant Hypertension, Aldosterone, and Persistent Intravascular Volume Expansion</subtitle>
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چکیده
منابع مشابه
Characterization of resistant hypertension: association between resistant hypertension, aldosterone, and persistent intravascular volume expansion.
BACKGROUND Resistant hypertension is a common clinical problem and greatly increases the risk of target organ damage. METHODS We evaluated the characteristics of 279 consecutive patients with resistant hypertension (uncontrolled despite the use of 3 antihypertensive agents) and 53 control subjects (with normotension or hypertension controlled by using <or=2 antihypertensive medications). Part...
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Resistant hypertension is defined as an elevated blood pressure in spite of treatment with 3 different antihypertensive agents. The prevalence of resistant hypertension is unknown, but recent cross-sectional analyses and hypertension outcome studies suggest it is a common clinical problem and will become even more so with an aging and increasingly heavy population. Secondary causes of hypertens...
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Hypertension resistant to 2 antihypertensive drugs is more common among obese patients than among lean patients. The case we describe and the observations we report suggest that refractoriness among obese hypertensives is frequently caused by obstructive sleep apnea and/or inappropriately high plasma aldosterone levels. In other words, obese hypertensives may have sleep apnea, obese hypertensiv...
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Sir, Essential hypertension resistant to treatment often warrants suitable investigations to exclude underlying secondary causes. Aldosterone renin ratio (ARR) is an effective diagnostic tool for detecting primary hyperaldosteronism among patients with presumed essential hypertension. Further confirmation of existing adrenal tumours or hyperplasia can be obtained with imaging studies such as hi...
متن کاملVascular responsiveness in rats resistant to aldosterone-salt hypertension.
Wistar-Furth rats have been shown to be resistant to mineralocorticoid-salt hypertension, but the mechanism for this resistance is unknown. In the current experiments, adult male Wistar and Wistar-Furth rats were given a subcutaneous aldosterone infusion (0.15 microgram/hr) for 4 weeks, and changes in blood pressure and vascular reactivity were studied. Rats received a 1% NaCl, 0.2% KCl solutio...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 2008
ISSN: 0003-9926
DOI: 10.1001/archinte.168.11.1159