Characterization of P0, a Ribosomal Phosphoprotein ofPlasmodium falciparum
نویسندگان
چکیده
منابع مشابه
Characterization of P0, a ribosomal phosphoprotein of Plasmodium falciparum. Antibody against amino-terminal domain inhibits parasite growth.
A cDNA expression clone of the human malarial parasite Plasmodium falciparum, lambdaPf4, which was reactive only to the immune sera and not to the patient sera, has recently been found to be the P. falciparum homologue of the P0 ribosomal phosphoprotein gene. A Northern analysis of the P0 gene revealed the presence of two transcripts, both present in all the different intraerythrocytic stages o...
متن کاملAntibodies against ribosomal phosphoprotein P0 of Plasmodium falciparum protect mice against challenge with Plasmodium yoelii.
Antibodies against the Plasmodium falciparum P0 ribosomal phosphoprotein (PfP0) have been detected exclusively but extensively in malaria-immune persons. Polyclonal rabbit and mice sera were raised against two recombinant polypeptides of P. falciparum P0 protein, PfP0N and PfP0C, covering amino acids 17 to 61 and the remaining amino acids 61 to 316, respectively. Sera against both these domains...
متن کاملNucleotide sequence of a rice acidic ribosomal phosphoprotein P0 cDNA.
The eukaryotic 38-kD acidic ribosomal protein PO is localized to the stalk of the 60s ribosomal subunit, forming a pentameric complex with dimers of 13-kD acidic ribosomal proteins P1 and P2 (Rich and Steitz, 1987). P1 (P2) and PO are analogous to Escherichia coli ribosomal protein L7/L12, and L10, respectively, and are thought to have the same functions as their prokaryotic counterparts, i.e. ...
متن کاملCloning and characterization of the gene encoding ribosomal P0 phosphoprotein from Neurospora crassa.
A gene for ribosomal protein P0 that belongs to the family of ribosomal P proteins was isolated from a Neurospora crassa cDNA library, using polyclonal antibodies against recombinant P0 protein from Saccharomyces cerevisiae. This is the first gene for ribosomal P0 protein to be cloned from filamentous fungi. The derived P0 protein sequence has a strong homology to other eukaryotic P0 proteins; ...
متن کاملFunctional complementation of yeast ribosomal P0 protein with Plasmodium falciparum P0.
A complex of three phosphoproteins (P0, P1 and P2) constitutes the stalk region at the GTPase center of the eukaryotic large ribosomal subunit, amongst which the protein P0 plays the most crucial role. Earlier studies have shown the functional complementation of the conditional P0-null mutant of Saccharomyces cerevisiae (W303dGP0) with orthologous P0 genes from fungal and mammalian organisms, b...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.18.12138