Characterization of kinin receptors modulating neurogenic contractions of the mouse isolated vas deferens
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چکیده
منابع مشابه
Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type.
The present study was designed to further characterize the presynaptic muscarinic M1-receptor responsible for the inhibition of neurogenic contractions in the isolated rabbit vas deferens. Electrically induced twitch contractions of this preparation were inhibited by the M1-agonist, McN-A-343, and by some of its analogs: 4-chloro-phenyl derivative greater than McN-A-343 greater than trans-olefi...
متن کاملThermodynamic parameters for [D-Pen2,5]enkephalin at delta-opioid receptors in the mouse isolated vas deferens.
Dissociation constants (KA) for [D-Pen2,5]enkephalin (DPDPE) inhibition of the electrically evoked twitch of the mouse isolated vas deferens preparation (MVD) were calculated at five temperatures (25, 30, 34, 37 and 40 degrees C). These values were determined from the equiactive concentrations obtained before (A) and after (A') partial irreversible blockade of a fraction of the receptor populat...
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D-004, a lipid extract of Roystonea regia fruits that contains oleic, lauric and myristic acids as major components inhibits alpha1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 microg/mL), oleic (100 microg/mL), laur...
متن کاملEffects of calcium-entry modulators on the biphasic neurogenic contractions in the circular muscle of guinea pig vas deferens.
Effects of nifedipine (10(-8)-10(-6) M), verapamil (10(-6)-3 x 10(-5) M) and Bay k 8644 (10(-7) M) on the contractions induced by transmural nerve stimulation or agonists were investigated in the circular smooth muscle of guinea pig vas deferens using a ring preparation. Transmural stimulation (20 Hz for 20 sec) produced biphasic contractions consisting of initial phasic and secondary tonic com...
متن کاملCyclophosphamide Treatment Alters the Contractility of Isolated Rat Vas Deferens.
Influence of cyclophosphamide treatment (40. mg/kg, ip on alternate days for 5 times) was assessed on 1 m mol BaCl2-induced in vitro rhythmic contractions in isolated rat vas deferens. The mean frequency (contractions per min) and amplitude (g tension) of rhythmic contractions were significantly decreased in the tissues isolated from cyclophosphamide-treated rats as compared to the control tiss...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1995
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1995.tb13372.x