Characterization of imatinib-resistant K562 cell line displaying resistance mechanisms
نویسندگان
چکیده
منابع مشابه
Multidrug resistance in tumour cells: characterization of the multidrug resistant cell line K562-Lucena 1.
Multidrug resistance to chemotherapy is a major obstacle in the treatment of cancer patients. The best characterised mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein. However, the resistance process is multifactorial. Studies of multidrug resistance mechanisms have relied on the analysis of cancer cell lines that have been selected...
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OBJECTIVE To study the biological characteristics and resistant mechanisms of the cisplatin-resistant human hepatocellular carcinoma (HCC) cell line. METHODS The study took place in the Department of Pharmacology, Chongqing Medical University, Chongqing, China, between April 2005 and November 2007. A resistant HCC cell line (QGY/CDDP) was established by stepwise increasing cisplatin (CDDP) co...
متن کاملCharacterization and resistance mechanisms of a 5-fluorouracil- resistant hepatocellular carcinoma cell line.
PURPOSE The chemoresistance of human hepatocellular carcinoma (HCC) to cytotoxic drugs, especially intrinsic or acquired multidrug resistance (MDR), still remains a major challenge in the management of HCC. In the present study, possible mechanisms involved in MDR of HCC were identified using a 5-fluorouracil (5-FU) -resistant human HCC cell line. METHODS BEL-7402/5-FU cells were established ...
متن کاملCharacterization of a K562 Multidrug-resistant Cell Line1
A daunorubicin-resistant variant of the K562 human leukemia cell line (K562-R), which demonstrates cross-resistance to other anthracycline antibiotics and Vinca alkaloids, has been developed in vitro by continuous exposure to daunorubicin. Cross-resistance to anthracyclines and Vinca alkaloids is reversed when cells are exposed to drugs in the presence of verapamil, a calcium channel blocker. T...
متن کاملThe Anti-cancer effects of Celastrol on K562 cell line
Background and Objective: The level of NF-κB factor expression (a transcriptional factor which increases the expression of inflammatory genes) is often increased in various human cancers. Therefore, NF-κB inhibitors such as Celastrol may prevent cancer development. The purpose of this study was to evaluate the anticancer effects of Celastrol on K562 cells proliferation. Materials and Methods:...
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ژورنال
عنوان ژورنال: Cellular and Molecular Biology
سال: 2018
ISSN: 1165-158X
DOI: 10.14715/cmb/2018.64.6.5