Characterization of Ghrelin O-Acyltransferase (GOAT) in goldfish (Carassius auratus)

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Characterization of Ghrelin O-Acyltransferase (GOAT) in goldfish (Carassius auratus)

Ghrelin is the only known hormone posttranslationally modified with an acylation. This modification is crucial for most of ghrelin's physiological effects and is catalyzed by the polytopic enzyme ghrelin O-acyltransferase (GOAT). The aim of this study was to characterize GOAT in a teleost model, goldfish (Carassius auratus). First, the full-length cDNA sequence was obtained by RT-PCR and rapid ...

متن کامل

Gill metaplasia in a goldfish, Carassius auratus auratus (L.).

1 Environmental Medicine Consortium, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA 2 Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA 3 North Carolina Zoological Park, Asheboro, NC, USA 4 Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Me...

متن کامل

Latent inhibition experiments with goldfish (Carassius auratus).

Evidence of latent inhibition was sought in a series of experiments with goldfish. In Experiment 1, goldfish were given nonreinforced preexposure to a color that subsequently predicted shock in an activity conditioning situation; their performance did not differ from that of control animals preexposed to a markedly different color. In Experiment 2, a group of goldfish given nonreinforced preexp...

متن کامل

Isolation of Shewanella putrefaciens from Goldfish (Carassius auratus auratus)

In the present study, the etiological agent that caused mortality in goldfish at an aquarium company located in Bursa in northwestern Turkey was identified. Diseased fish were lethargic, displaying a loss of appetite, ascites, and exophthalmia. Internal examination revealed that the kidney was surrounded by exudate and that the spleen and liver were pale. Microbiological examination showed that...

متن کامل

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.

The discovery of ghrelin O-acyltransferase (GOAT) opens the way to the design of drugs that block the attachment of an octanoyl group to the appetite-stimulating peptide hormone ghrelin, potentially preventing obesity. Here, we develop a biochemical assay that uses membranes from insect cells infected with baculovirus encoding mouse GOAT. The GOAT-containing membranes transferred the [(3)H]octa...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: PLOS ONE

سال: 2017

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0171874