Characterization of disease-associatedN-linked glycoproteins
نویسندگان
چکیده
منابع مشابه
Immunogenicity of the Multi-Epitopic Recombinant Glycoproteins of Newcastle Disease Virus: Implications for the Serodiagnosis Applications
Background: Newcastle disease virus (NDV) is a dangerous viral disease, infecting a broad range of birds, and has a fatal effect on the poultry industries. The attachment and consequently fusion of the virus to the host cell membrane is directed by the two superficial glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion (F) which is considered as the important tar...
متن کاملGlycoproteins in disease.
The class of carbohydrate macromolecules known as glycoproteins exhibits great structural diversity. Their key role in the function of biological systems includes determination of cell membrane structure and function as well as antigenic determinants. In the recent decade, the detection of inborn errors of metabolism of these macromolecules as well as changes in their composition following muta...
متن کاملCharacterization of human zona pellucida glycoproteins.
The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptides predicted from the human ZP2 and ZP3 cDNA, we identified ZP3 as a 53-60 kDa...
متن کاملCharacterization and structure of plasma glycoproteins.
The present state of knowledge of glycoproteins is briefly reviewed. The recent discovery of hitherto unknown extremely important biological functions of this class of macromolecules has given a new impetus to the basic research of glycoproteins. In an effort to understand the relationship between structure and function of these macroglobulins, the amino acid and monosaccharide sequences of the...
متن کاملCharacterization of Glycoproteins in Equine Herpesvirus-1
In this study, we attempted to express twelve glycoproteins of equine herpesvirus-1 (EHV-1) in 293T cells and to characterize these using monoclonal antibodies (MAbs) and horse sera against EHV-1. Expression of glycoprotein B (gB), gC, gD, gG, gI and gp2 was recognized by immunoblot analysis using horse sera, but that of gE, gH, gK, gL, gM and gN was not. Four MAbs recognized gB, four recognize...
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ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2013
ISSN: 1615-9853
DOI: 10.1002/pmic.201200333