Characterization of articular chondrocytes isolated from 211 osteoarthritic patients
نویسندگان
چکیده
منابع مشابه
Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.
PURPOSE To determine whether articular chondrocytes derived from osteoarthritic knee joints could evoke alloreactive proliferation of peripheral blood mononuclear cells (PBMC) and inhibit mitogenic activity of polyclonally activated CD4+ major histocompatibility complex (MHC) class II- restricted T cells in vitro. METHODS Osteoarthritic cartilages of 17 patients aged 61 to 85 years were harve...
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Background: Recent studies have provided evidence that integrins play roles in recognition of mechanical stimuli and its translation into a cellular response. Integrin signaling may be regulated by a number of mechanisms including accessory proteins such as CD98 (4F2 antigen). Objectives: To determine CD98 expression by human articular chondrocytes and its involvement in human articular mechano...
متن کاملBiological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes
BACKGROUND Phosphocitrate (PC) inhibits osteoarthritis (OA) in Hartley guinea pigs. However, the underlying molecular mechanisms remain poorly understood. OBJECTIVE This study sought to examine the biological effect of PC on OA chondrocytes and test the hypothesis that PC may exert its OA disease modifying effect, in part, by inhibiting the expression of genes implicated in OA disease process...
متن کاملUltrastructure of chondrocytes in osteoarthritic femoral articular cartilage.
BACKGROUND Osteoarthritis (OA) is a common problem in elderly, but it is not an inevitable feature of ageing. About 80-90% of individuals of both sexes have radiographic evidence of OA by the time they reach an age of 65. But not all of them have the symptoms like pain and decreased joint motion. OBJECTIVE The objective of the present study was conducted to find out whether the osteoarthritic...
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Mitochondria are involved in many cellular processes; mitochondrial dysfunctions have been associated with apoptosis, aging, and a number of pathological conditions, including osteoarthritis (OA). Mitochondrial proteins are attractive targets for the study of metabolism of the chondrocyte, the unique cell type present in mature cartilage, and its role in tissue degradation. Using a proteomics a...
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ژورنال
عنوان ژورنال: Cell and Tissue Banking
سال: 2013
ISSN: 1389-9333,1573-6814
DOI: 10.1007/s10561-013-9371-3