Characterization of an Extended-Spectrum Class C β-Lactamase ofCitrobacter freundii
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چکیده
منابع مشابه
Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.
An Ambler class A β-lactamase gene, bla(CIA-1), was cloned from the reference strain Chryseobacterium indologenes ATCC 29897 and expressed in Escherichia coli BL21. The bla(CIA-1) gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respectively. bla(CIA-1)-like genes were detected from clinical isolates. In addition...
متن کاملActivity of avibactam against Enterobacter cloacae producing an extended-spectrum class C β-lactamase enzyme.
BACKGROUND Extended-spectrum AmpC (ESAC) β-lactamase enzymes, which are either chromosomally encoded or plasmid encoded, have minor structural changes that broaden their substrate hydrolysis profile. The derepressed AmpC enzyme found once in Enterobacter cloacae CHE was shown to contain a six residue deletion in the H-10 helix in close proximity to the active site. Avibactam is a non-β-lactam i...
متن کاملCommunity Transmission of Extended-Spectrum β-Lactamase
land. Furthermore, Ct. felis often feeds on humans. Clinicians encountering patients with fever or rash (or both) and a history of cat contact or flea bites should consider a diagnosis of R. felis. Laboratory confirmation of infection is not easy, but in vitro culture of R. felis, and hence material for a serologic assay for the diagnosis of human R. felis infections, has recently been describe...
متن کاملThe effect of silver nanoparticles on Gram-negative bacilli Resistant to Extended-Spectrum Β-Lactamase Enzymes
Abstract: Background and objectives: Antibiotic resistant to Antimicrobial agents is one of the most important concern in hospitals, which can lead to increased costs, treatment fails and mortality rates. The aim of this study was identification of Gram-negative bacilli resistant to extended-spectrum β-lactamase Enzymes (ESBLs) and determination of the effect of silver nanoparticles on the...
متن کاملBiochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae.
We biochemically characterized the Klebsiella pneumoniae extended-spectrum SHV-55 enzyme carrying the amino acid substitutions Tyr73Phe (as in SHV-28) and Gly2383Ser and Glu2403Lys (both found in SHV-5) identified in a previous study (5). The SHV-55 extended-spectrum -lactamase differed from SHV-5 only in the signal peptide region (1). The blaSHV-55 gene was obtained as described by Mendonça et...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2001
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.2001.tb02619.x