Chaperone Potential of Pulicaria undulata Extract in Preventing Aggregation of Stressed Proteins
نویسندگان
چکیده
منابع مشابه
Investigation the protective ability of Pulicaria. undulata aqueous extract on aggregation of κ -casein
Protein aggregation is phenomenon wherein protein loses its native structure and aggregates due to the adaption of non-native conformation. Amyloid aggregation formed by the accumulation of various proteins causes many diseases in humans and other organisms. Antioxidants can prevent proteins aggregation. Pulicaria undulata extract along with phenolic compounds can increase protein stability an...
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Pulicaria species, such as Pulicaria undulata, are rich in sesquiterpene lactones. The methylene chloride/ methanol (1:1) extract of P. undulata resulted in the isolation of new sesquiterpenes (1–4), as well as previously reported metabolites (5–14). Structures were elucidated by spectroscopic analyses. Using a mouse peritoneal macrophage bioassay, lipopolysaccharide-induced nitric oxide inhibi...
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Objective: To evaluate the in vitro cytotoxicity, antioxidant activities and structure-activity relationship of secondary metabolites isolated from Pulicaria
متن کاملAha1 can act as an autonomous chaperone to prevent aggregation of stressed proteins.
Aha1 (activator of Hsp90 ATPase) stimulates the ATPase activity of the molecular chaperone Hsp90 to accelerate the conformational cycle during which client proteins attain their final shape. Thereby, Aha1 promotes effective folding of Hsp90-dependent clients such as steroid receptors and many kinases involved in cellular signaling. In our current study, we find that Aha1 plays a novel, addition...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2014
ISSN: 1530-9932
DOI: 10.1208/s12249-014-0090-2