Changing pattern of perforated PUD: Are NSAIDs to be blamed?

Medical errors: who is to be blamed?

Well-Typed Programs Can't Be Blamed

We introduce the blame calculus, which adds the notion of blame from Findler and Felleisen’s contracts to a system similar to Siek and Taha’s gradual types and Flanagan’s hybrid types. We characterise where positive and negative blame can arise by decomposing the usual notion of subtype into positive and negative subtyping, and show that these recombine to yield naive subtyping. Naive typing ha...

Nephrogenic systemic fibrosis: is gadolinium to be blamed?

Nephrogenic Systemic Fibrosis is a sclero myxedema like systemic disorder characterized by erythematous, indurated, well-defined, plaques over the skin, seen commonly on limbs symmetrically, particularly in areas between ankle and mid-thigh and between wrist and mid-upper arm and also over trunk of the body. NSF is progressive, the plaques coalesce having ameboid advancing edge and skin becomes...

Can albuterol be blamed for lactic acidosis?

Albuterol is an uncommonly recognized culprit in causing lactic acidosis. While treating asthmatics, lactic acidosis creates a paradoxical situation in which, despite improvement in bronchospasm, patients look more dyspneic as a compensatory mechanism for metabolic acidosis. This might lead to misinterpretation of the situation with increased albuterol dosing, creating a sort of vicious cycle u...

NSAIDs in axial spondyloarthritis: to be continued…?

Phenylbutazone was discovered in 1946 and promptly exhibited efficacy in various rheumatic diseases in the early 1950s. Its efficacy on pain and general well-being was especially present in ankylosing spondylitis (AS), which was then known as ‘rheumatoid spondylitis’. 2 However, even in the early days, non-steroidal antiinflammatory drugs (NSAIDs) were not considered harmless drugs, as the toxi...