Changing incidence of positive direct Coombs test in inbred NZB-BL mice.

Changing incidence of positive direct Coombs test in inbred NZB-BL mice.

The. inbred NZB/BL mouse has been shown by Bielschowsky, Helyer, and Howie (1959) to develop auto-immune haemolytic anaemia spontaneously, and this disorder has been considered to be genetically determined (Holmes and Burnet, 1966). Burnet and Holmes (1962) described a characteristic thymic change in this 'auto-immune' strain of mice; and certain renal lesions have been noted (Holmes and Burnet...

Test in Inbred NZB/BL Mice

The. inbred NZB/BL mouse has been shown by Bielschowsky, Helyer, and Howie (1959) to develop auto-immune haemolytic anaemia spontaneously, and this disorder has been considered to be genetically determined (Holmes and Burnet, 1966). Burnet and Holmes (1962) described a characteristic thymic change in this 'auto-immune' strain of mice; and certain renal lesions have been noted (Holmes and Burnet...

Positive direct Coombs test induced by phenylhydrazine.

Immunoglobulins in Nzb/bl Mice

Determination of serum immunoglobulin levels in NZB and normal mice has indicated that an elevation of the gammaM-globulin level occurs in NZB mice. This can be demonstrated in young NZB mice well before other autoimmune manifestations are observed. A slight elevation of gammaM-globulin was also observed in NZB hybrid mice. Erythrocyte autoantibodies were analyzed by the direct Coombs' test wit...

Immunopathology of Nzb/bl Mice

A filtrable agent separable from transplantable malignant lymphomas of NZB/Bl mice was capable, upon inoculation into preweanling NZB/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys-renal functional and structural changes qualitatively similar to those of spontaneous o...